Increasing lutetium production while leveraging metabolic imaging to enhance theranostics effectiveness

ILLUMINATE is a collaborative research program which aims to demonstrate the unique value of Metabolic Magnetic Resonance Imaging (MeMRI), used to visualize chemical processes in the body, to significantly improve effective application of theranostics - an approach combining diagnosis, treatment, and continuous follow up of a condition. ILLUMINATE will provide the first clinical translation of MeMRI, with application to castrate resistant metastatic prostate cancer. This will pave the way for future expansion of the technology for use in earlier cancer stages and in other cancer types.

In parallel, ILLUMINATE seeks to increase the overall availability of lutetium - a highly promising targeted radioligand therapy recently approved for metastasized prostate cancer, and develop more sustainable production methods for it.

The ILLUMINATE consortium covers a wide range of expertise

From fundamental technology development to final optimisation and upscaling, to clinical validation and healthcare integration.

The consortium brings together pioneers of the MeMRI technology, both in an academic and industrial setting, and provides expertise in both development of imaging technology and production of radionuclide medicine.

To realize patient-centered innovation in the MeMRI field, the consortium will link technology development to expertise in clinical validation. To ensure wide adoption of project results, all partners will collaborate closely in regulatory and educational activities on healthcare integration.

Our partnership

ILLUMINATE is a four-and-a-half-year public-private partnership, funded by the Innovative Health Initiative (IHI).

Among ILLUMINATE’s partners are MedTech companies, research institutes, university hospitals and small- and medium-sized enterprises. ILLUMINATE’s partners are:

UMC Utrecht, Euro-Bioimaging ERIC, Philips Medical Systems Nederland BV, Philips Gmbh Innovative Technologies, Synlab Sdn Spa, Consiglio Nazionale Delle Ricerche, University of Turin, Bracco Imaging Spa, Tesla Dynamic Coils BV, Wavetronica BV, Lund University, NRG PALLAS, Amsterdam UMC, University Hospital Essen, Lygature.

 

The consortium is coordinated by UMC Utrecht, together with NRG PALLAS as a project lead.

Acknowledgement of support

This project is supported by the Innovative Health Initiative Joint Undertaking (IHI JU) under grant agreement No 101172722. The JU receives support from the European Union’s Horizon Europe research and innovation programme and COCIR, EFPIA, Europa Bío, MedTech Europe, and Vaccines Europe.

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Copyright (c) 2024 by Lygature | Terms & Conditions | Privacy policy | Cookies policy

Terms & Conditions

Terms and conditions These Terms and Conditions were modified on November 1, 2024.

This ILLUMINATE website (the “Website”) is published by Foundation (Stichting) Lygature (“Lygature”) on behalf of the ILLUMINATE initiative. Lygature is a not-for-profit organization registered in Utrecht, The Netherlands with registered number 28111472 whose registered office is at Jaarbeursplein 6, 3521 AL Utrecht, The Netherlands.

These terms and conditions of use (“Terms of Use”) apply to all visits to and use of this Website, as well as to all information, recommendations and/or services provided to you on or through this Website (the “Information”). By using this Website, you confirm that you accept these terms or use and that you agree to comply with them. Lygature may amend these Terms of Use from time to time. Every time you wish to use this Website, please check these Terms of Use to ensure you understand the terms that apply at that time.

Our Website is directed to people residing in Europe. Lygature does not represent that content available on or through our Website is applicable or appropriate for use in other countries.

Information and Liability
The Information contained on our Website is for general information purposes only and does not constitute advice. You must obtain professional or specialist advice before taking, or refraining from, any action based on the content on the Website. Although we make reasonable efforts to update the Information on the Website, Lygature makes no representations, warranties or guarantees, whether express or implied, that the Information, or any other content on the Website is accurate, complete or up to date.

Please note that this Website is intended only for domestic and private use and you agree not to use our Website for any commercial or business purpose.

Lygature will not be liable for any loss or damages resulting from, or in connection with, the use of (or inability to use) the Website, including damages caused by viruses or any incorrectness or incompleteness of the Information. Lygature will further not be liable for damages resulting from the use of electronic means of communication, including – but not limited to – damages resulting from failure or delay in delivery of electronic communications, interception or manipulation of electronic communications by third parties or by computer programs used for electronic communications and transmission of viruses. Nothing in these Terms of Use shall exclude or limit in any way Lygature’s liability where it would be unlawful to do so. This includes liability for death or personal injury cause by gross negligence, fraud or fraudulent misrepresentation on the part of Lygature,

Linked Sites
This Website provides links to external internet sites and resources provided by third parties. These links are provided for your information only and Lygature has no control over them. Lygature will not be liable for the use or the content of internet sites that link to this Website or which are linked from it. Our Privacy Policy does not apply to any collection and processing of your personal data on or through such other external websites.

Intellectual Property
All rights to this Website and the Information, including copyrights and other intellectual property rights, are owned by Lygature or licensed to it by the rights’ owner(s). Users are permitted to read the Website and the Information and make copies for their own personal use, for example by printing or storing it. You may not use any part of the content on our Website for public or commercial purposes without our permission. Any unauthorized use of the images or content on our Website may violate copyright laws, trade mark laws or the laws of privacy and publicity,

In the event you send to Lygature or the ILLUMINATE initiative by e-mail or otherwise unsolicited ideas and/or materials, whether consisting of texts, images, sounds, software, information or otherwise (the “Materials”), Lygature will be entitled to use, copy and/or commercially exploit such Materials to the fullest extent and free of charge and Lygature will not be bound by any confidentiality obligation in respect of such Materials. You hereby indemnify and hold Lygature harmless from and against all actions, claims and liabilities, suffered, incurred or sustained by Lygature as a result of the use and/or exploitation of the Materials infringing the (intellectual property) rights of any third party or otherwise being unlawful towards a third party.

Rules about linking to our Website
You may link to the homepage of this Website, providing you do so in a way that is fair and legal and does not damage - or take advantage of - the reputation of either ILLUMINATE or Lygature. You must not establish a link in such a way as to suggest any form of association or approval or endorsement from either ILLUMINATE or Lygature where none exists. You must not establish a link to our site in any website that is not owned by you. Lygature reserves the right to withdraw linking permission without notice.

If you wish to link to or make use of content on the Website other than set out in these Terms and Conditions, please contact Lygature (info@lygature.org)

Personal Information
Lygature will only use your personal information as set out in our Privacy Policy, please see here. In addition, our Website uses ‘cookies’ to analyse site traffic. For more information about our use of Cookies please refer to our Cookie Policy here.

Complaints
If you have a question or complaint about this website, please contact Lygature
(info@lygature.org).

Applicable Law and Jurisdiction
These Terms of Use will be exclusively governed by Dutch law. All disputes arising in connection with these Terms of Use, including disputes concerning the existence and validity thereof, will be resolved by the competent courts of Utrecht.

Privacy Policy

This Privacy Policy was modified on November 1, 2024.

We know that the security of your personal data is an important concern, and we take the protection of personal data very seriously. As a result, we would like you to understand how we collect, process and use personal data through your use of this Website, including any data you may provide through this Website when you sign up to our newsletter or submit an inquiry or comment. We recommend that you read this Privacy Policy so that you understand our approach towards the use of your personal data. Personal data means any information about an individual from which that person can be identified. It does not include data where the identify has been removed (anonymous data).

In all cases, the ILLUMINATE initiative complies with the applicable laws and regulations. This means that:

• We will process your personal data in accordance with the purpose they were provided for, these purposes and related type of personal data are described in the privacy policy;

• Processing of your personal data is limited to data minimally needed for the purposes they are processed for;

• We have taken appropriate technical and organizational measures to safeguard the security of your personal data; • We are aware of your rights regarding your personal data, we want to point these out and will respect those.

• By submitting your personal data to us, you will be treated as having given your permission – where necessary and appropriate – for disclosures referred to in this Privacy Policy.

Special notice - if you are under 18 years old
Our website is not aimed at children under 18 years old and we will not collect, use, provide or process in any other form any personal data of children under the age of 18 deliberately. We therefore also ask you, if you are under 18 years old, please do not send us your personal data (for example, your name, address and email address). If you are under 18 years old and you nevertheless wish to ask a question or use this website in any way which requires you to submit your personal data, please get your parent or guardian to do so on your behalf.

Who is responsible for the personal information collected on this site? ILLUMINATE is made up of different legal entities. This Privacy Policy is issued on behalf of ILLUMINATE so when we mention ILLUMINATE, “we”, “us” or “our” we are referring to the relevant company in the ILLUMINATE responsible for processing your data. Foundation (Stichting) Lygature, a not-for-profit organization registered in Utrecht, The Netherlands with registered number 28111472 whose registered office is at Jaarbeursplein 6, 3521 AL Utrecht, The Netherlands is the owner and responsible for this Website.

We have appointed a data protection officer (DPO) who is responsible for overseeing questions in relation to this Privacy Policy. If you have any questions about this Privacy Policy, including any requests to exercise your legal rights, please contact the DPO using the details set out below.

The data we collect from you
We may collect, use, store and transfer different kinds of personal data about you which we have grouped together below as follows:

• Notification and Communication
Data which includes information you provide us for subscribing to our email notifications and/or newsletters, the communication content and metadata associated with the communication. Our website will generate the metadata associated with the communications made using website contact forms.

Publication Data which includes information that you post for publication on our website or through our services.

Voluntary Profile Data which includes any information you may choose to submit on the Website such as [title, first name, last name, gender, occupation, employer’s name, function, professional address, (business) e-mail address, telephone number, username or other identifier, password, profile picture.

Technical Data which includes anonymized internet protocol (IP) address, geographical location based on the anonymized IP address, cookie tracking is used based on your consent, time zone setting, browser plug-in types and versions, operating system and platform. The source of usage data is Matomo Analytics Cloud by InnoCraft.

User Data which includes information about how you use our website and service such as referral source, length of visit, page views and website navigation paths as well as information about the timing, frequency and pattern of your service of use. The source of usage data is Matomo Analytics Cloud by InnoCraft.

Aggregated Data: In addition, we may automatically collect information about the Website that you came from or are going to, information on the parts of the Website that you visit, the type of browser you use and the time you access the Website. However, this information is aggregated and therefore not used to identify you. If for any reason we combine or connect Aggregated Data with your personal data so it can directly or indirectly identify you, we treat the combined data as personal data which will be used in accordance with this Privacy Policy.

We do not collect any Special Categories of Data which includes details about your race or ethnicity, religious or philosophical beliefs, sex life, sexual orientations, political opinions, trade union membership, information about your health and genetic and biometric data.

How we use your personal data
One of the purposes of our website is to inform you of who we are and what we do. We have set out below in table format, a description of all the ways we plan to use your personal data, and which of the legal bases we rely on to do so. We have also identified our legitimate interest, where appropriate. Please note that we may process your data for more than one lawful ground depending on the specific purpose for which we are using your data. Please contact us if you need details about the specific legal ground we are relying on to process your personal data where more than one ground has been set out in the table below.

If at any time you wish us to stop using your personal data for any or all of the purposes set out in the table, please contact us (details below). Unless otherwise restricted by any applicable law, we will stop the use of your personal data for such purposes as soon as it is reasonably possible to do so.

Purpose/Activity

Type of Data

Lawful basis for processing including basis of legitimate interest

To send newsletters and invitations for events

Notification and Communication Data

Consent

To deliver relevant website content to you

Personal Account Data / Voluntary Profile Data / Notification and Communication Data

Performance of a contract with you

Enabling a publication and administering our website and services

Publication Data

Consent

Analysing the use of the website

Usage Data

Consent / Our Legitimate Interest, namely monitoring and improving our website and services

Record-keeping

Notification and Communication Data

Our Legitimate Interest, namely the proper administration of our website and business

If we need to use your personal data for an unrelated purpose, we will notify you and we will explain the legal basis which allows us to do so.

Please note that in addition to the instances set out above we may need to process your personal data without your knowledge or consent where this is required or permitted by law or in order to protect your vital interests or the vital interests of another person.

Change of purpose
We will only use your personal data for the purposes for which we collected it, unless we reasonably consider that we need to use it for another reason and that reason is compatible with the original purpose. If you wish to get an explanation as to how the processing for the new purpose is compatible with the original purpose, please contact us.

Disclosure of your personal data
As part of the administration of our Website we might need to share your personal data with third parties such as:

• Service Providers located in The Netherlands acting as processors who provide IT and system administration services. In particular, Lygature employs the services of Betawerk to act as the Hosting Provider. The Hosting Provider hosts all data received through the Website on their secured server. Lygature employs Betawerk as the Site Developer. The Site Developer maintains and develops the Website. Lygature will, at all times, control and be responsible for the use of your information and ensure that the Hosting Provider and Site Developer processes your personal data in accordance with all applicable data protection laws.

• Website analytics services are provided by InnoCraft, 7 Waterloo Quay PO625, 6140 Wellington, New Zealand. All the data gathered is stored in Germany and backed-up in Ireland.

We require all third parties to respect the security of your personal data and to treat it in accordance with the law. We do not allow our third-party service providers to use your personal data for their own purposes and only permit them to process your personal data for the purposes that we have agreed with you and in accordance with our instructions. We request those third parties to implement adequate levels of protection in order to safeguard your personal data.

We will get your express opt-in consent before we share your personal data with any third party for marketing purposes. You can ask us or third parties to stop sending you marketing messages at any time by following the opt-out links on any marketing message sent to you or contacting us at any time.

Except as set out in this Privacy Policy, we will not disclose any personally identifiable data without your permission unless we are legally entitled or required to do so (for example, if required to do so by legal process or for the purposes of prevention of fraud or other crime) or if we believe that such action is necessary to protect and/or defend our rights, property or personal safety and those of our users/customers or other individuals.

International Transfers
Some of the third parties identified in the section above are located outside of the European Economic Area (EEA) so the processing of your data will involve a transfer of data outside of the EEA. Whenever we transfer your data out of the EEA we ensure a similar degree of protection is afforded to it by ensuring at least one of the following safeguards is implemented:

• We will only transfer your personal data to countries that have been deemed to provide an adequate level of protection for personal data by the European Commission;

• Where we use certain service providers we may use specific contracts approved by the European Commission which give personal data the same protection it has in Europe.

• Where we use providers based in the US, we may transfer data to them if they are part of the Privacy Shield which requires them to provide similar protection to personal data shared between Europe and the US.

We respect your personal data and therefore, we will take steps to ensure that your privacy rights continue to be protected if we transfer your personal data outside of the EEA in this way. In addition, if you use our services while you are outside the EEA, your personal data may be transferred outside the EEA in order to provide you with those services.

Keeping our records accurate
We aim to keep your personal data as accurate as possible. If you would like to review, change or delete the details you have supplied us with, please contact us as set out below.

Security of your personal data
We have implemented appropriate security measures and policies with the objective of protecting your personal data from unauthorized access and improper use and will update these measures as new technology becomes available, as appropriate. In addition, we limit access to your personal data to those employees, agents, contractors and other third parties who have a business need to know. They will only process your personal data on our instruction and they are subject to a duty of confidentiality.

Data retention
We only retain personal data for as long as is reasonably necessary to fulfil the purposes we collected it for, including the purpose of satisfying any legal, regulatory or reporting requirements. We may retain your personal data for a longer period in the event of complaint or if we reasonably believe there is a prospect of litigation. To determine the appropriate retention period for personal data, we consider the amount, nature and sensitivity of the personal data, the potential risk of harm from unauthorized use or disclosure of your personal data and the purposes for which we process your personal data and whether we can achieve those purposes through other means, and the applicable legal, regulatory or other requirements.

Use of your personal data submitted to other websites
On our website, we may have links to other websites, or you may be referred to our website through a link from another website. Please note that we cannot be responsible for the privacy policies and practices of other websites. Such content is subject to their terms of use and any additional guidelines and privacy information provided in relation to that use on their website.

Cookies policy
Cookies are small data files that your browser places on your computer or device, designed to help your browser navigate a website. Cookies themselves cannot collect any data stored on your computer or your files. To protect your privacy, your browser only gives a website access to the cookies it has already sent to you. We use cookies to learn more about the way you interact with our website content and help us to improve your experience when visiting our website. For details of how cookies are used, see our Cookies policy.

Changes to our Privacy Policy
From time to time we may make changes to this Privacy Policy. Please check our Privacy Policy on a regular basis. This Privacy Policy was last updated on the date presented at the top of this page. Historic versions of our Privacy Policy are available on request.

Your rights
Under certain circumstances you have rights under data protection laws in relation to your personal data. Some of the rights are complex and not all of the details have been included in the summary below. Accordingly, you should read the relevant laws and guidance from the regulatory authorities for a full explanation of these rights.

Your principal rights under data protection law are:

• The right to access: this enables you to receive a copy of the personal data we hold about you and to check that we are lawfully processing it.

• The right to rectification: this enables you to have any incomplete or inaccurate data we hold about you corrected, though we may need to verify the accuracy of the new data you provide us.

• The right to erasure: this enables you to ask us to delete or remove personal data where there is no good reason for us to continue processing it. Note, however, that we may not always be able to comply with your request for erasure for specific legal reasons which will be notified to you, if applicable, at the time of the request.

• The right to object to processing: this enables you to object to our processing of your data if you feel it impacts your fundamental rights or freedoms. You also have the right to object to processing where we are using data for direct marketing purposes. Note, however, that in some cases we may demonstrate we have a compelling legitimate ground to process your information that overrides your fundamental rights or freedoms.

• The right to restrict processing: this enables you to ask us to suspend the processing of your data if you want us to establish the data’s accuracy, where processing us unlawful but you oppose erasure, we no longer need the personal data for processing but you require us to hold it for the establishment, exercise or defence of legal claims ad you have objected to the grounds of processing but we need to verify if we have overriding legitimate grounds to use it

• The right to data portability: this enables you to ask us to transfer the personal data to you or a third party chosen by you. Note this right only applies to automated information you initially provided consent for is to use or where we use this information to perform a contract with your data • The right to complain to a supervisory authority

• The right to withdraw consent: this applies when you have provided your consent to our processing but does not affect the lawfulness of processing carried out before your withdraw your consent.

If you wish to exercise any of the rights set out above, please contact us (details below). We may need to request specific information from you in order to help us confirm your identify and ensure your rights to access your personal data (or exercise any of your other rights). This is a security measure to ensure that personal data is not disclosed to any person who has no right to receive it. We may also contact you to ask you for further information in relation to your request to speed up our response.

How you can contact us
If you would like to contact us about this Privacy Policy or our privacy practices, please contact Lygature (info@lygature.org).

Cookies policy

In this policy we use the term “cookies” to refer to cookies and other similar technologies covered by the EU Directive on privacy in electronic communications.

What is a cookie?
Cookies are small data files containing an identifier (a string of letters and numbers) that is sent by a web server to a web browser and is stored by the browser. The identifier is then sent back to the server every time the browser requests a page from the server. Cookies help your browser navigate a website and the cookies themselves cannot collect any information stored on your computer or your files. When a server uses a web browser to read cookies they can help a website deliver a more user-friendly service. To protect your privacy, your browser only gives a website access to the cookies it has already sent to you. Cookies do not typically contain any information that personally identifies a user, but personal information that we store about you may be linked to the information stored in and obtained from cookies.

Cookies that we use
We use the following cookies:

Strictly necessary cookies. These are cookies that are required for the operation of our website. They include, for example, cookies that enable you to log into secure areas of our website

Analytical/performance cookies. They allow us to recognize and count the number of visitors and to see how visitors move around our website when they are using it. This helps us to improve the way our website works, for example, by ensuring that users are finding what they are looking for easily.

How are third party cookies used?
For some of the functions within our websites we use third party suppliers, for example, when you visit a page with videos embedded from or links to YouTube. These videos or links (and any other content from third party suppliers) may contain third party cookies and you may wish to consult the policies of these third-party websites for information regarding their use of cookies.

How do I reject and delete cookies
We will not use cookies to collect personally identifiable data about you. However, should you wish to do so, you can choose to reject or block the cookies set by this Website or the websites of any third-party suppliers by changing your browser settings – see the Help function within your browser for further details. Please note that most browsers automatically accept cookies so if you do not wish cookies to be used you may need to actively delete or block the cookies.

You can also visit www.allaboutcookies.org for details on how to delete or reject cookies and for further information on cookies generally. For information on the use of cookies in mobile phone browsers and for details on how to reject or delete such cookies, please refer to your handset manual.

Note, however, that if you reject the use of cookies you will still be able to visit our websites but some of the functions may not work correctly.

How you can contact us
If you would like to contact us about this Cookie Policy, please contact
Lygature info@lygature.org.

Disclaimer
The content on this website reflects only the author's view and neither IHI nor the European Union, EFPIA, or any Associated Partners are responsible for any use that may be made of the information contained therein.